Assay Detail
Functional
CHEMBL5257533
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Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.01 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 10.00 |
| CHEMBL5289731 | — | — | 1 | 8.10 |
| CHEMBL5276244 | — | — | 1 | 7.52 |
| CHEMBL5266999 | — | — | 1 | 7.40 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.22 |
| CHEMBL5272343 | — | — | 1 | 7.22 |
| CHEMBL5268902 | — | — | 1 | 6.70 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.08 |
| CHEMBL5284247 | — | — | 1 | 5.13 |
| CHEMBL5280611 | — | — | 1 | 4.68 |
| CHEMBL5285740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5289731 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5276244 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5266999 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5272343 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5268902 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5284247 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL5280611 | — | IC50 | = | 20900.0 | nM | 4.68 |
| CHEMBL5285740 | — | IC50 | > | 30200.0 | nM | - |