Assay Detail
Functional
CHEMBL5257558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse EL4 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | EL4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.31 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 10.00 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.22 |
| CHEMBL5266999 | — | — | 1 | 6.09 |
| CHEMBL5289731 | — | — | 1 | 5.00 |
| CHEMBL5284247 | — | — | 1 | 4.88 |
| CHEMBL5280611 | — | — | 1 | 4.65 |
| CHEMBL5285740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5266999 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5289731 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL5284247 | — | IC50 | = | 13140.0 | nM | 4.88 |
| CHEMBL5280611 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL5285740 | — | IC50 | > | 30200.0 | nM | - |