Assay Detail

CHEMBL5257572

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Functional

Antiproliferative activity against human SK-MEL cells assessed as reduction in cell growth inhibition

ChEMBL ↗

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Target

SK-MEL (CHEMBL614914) ↗

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SK-MEL (CHEMBL614914) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target SK-MEL

CHEMBL614914

Anchored from Assay target.

Protein identity SK-MEL

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	SK-MEL
Confidence	1 — Organism
Curated By	Autocuration

Target

SK-MEL (CHEMBL614914) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents.

Fröhlich T, Çapcı Karagöz A, Reiter C, Tsogoeva SB.
J Med Chem (2016) 59 : 7360 -7388
PubMed 27010926 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.39	10.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL428647	PACLITAXEL	4.0	1	10.00
CHEMBL53463	DOXORUBICIN	4.0	1	6.77

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL428647	PACLITAXEL	IC50	=	0.1	nM	10.00
CHEMBL53463	DOXORUBICIN	IC50	=	170.0	nM	6.77