Assay Detail
Binding
CHEMBL5257601
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Inhibition of DENV2 recombinant NS2B-(G4-S-G4)-NS3 protease using Bz-nKRR-AMC as substrate preincubated for 30 mins followed by substrate addition measured after 30 mins by fluorescence spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | dengue virus type 2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Progress and prospects on DENV protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.10 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468049 | — | — | 1 | 5.17 |
| CHEMBL256877 | — | — | 1 | 5.02 |
| CHEMBL522355 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468049 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL256877 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL522355 | — | IC50 | = | 167000.0 | nM | - |