Assay Detail
Binding
CHEMBL5257682
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of heparanase (unknown origin) incubated for 18 hrs by fondaparinux assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent advances in the discovery of heparanase inhibitors as anti-cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.83 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5279386 | — | — | 1 | 7.92 |
| CHEMBL5268939 | — | — | 1 | 7.70 |
| CHEMBL5266136 | — | — | 1 | 6.38 |
| CHEMBL5286425 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5279386 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5268939 | — | IC50 | = | 19.8 | nM | 7.70 |
| CHEMBL5266136 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL5286425 | — | IC50 | = | 4820.0 | nM | 5.32 |