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Assay Detail

CHEMBL5258024

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of farnesyltransferase (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Side Chain Cyclized Aromatic Amino Acids: Great Tools as Local Constraints in Peptide and Peptidomimetic Design.
Van der Poorten O, Knuhtsen A, Sejer Pedersen D, Ballet S, Tourwé D.
J Med Chem (2016) 59 : 10865 -10890
PubMed 27690430 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.14 9.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5269045 1 9.43
CHEMBL328773 1 9.22
CHEMBL5276568 1 9.00
CHEMBL5288816 1 8.30
CHEMBL5286303 1 7.96
CHEMBL5275025 1 7.70
CHEMBL289302 1 7.43
CHEMBL5276439 1 6.92
CHEMBL5280712 1 6.80
CHEMBL5276077 1 6.60
CHEMBL5286776 1 6.57
CHEMBL5266332 1 6.00
CHEMBL5285866 1 4.00
CHEMBL5265851 1 4.00
CHEMBL308283 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5269045 IC50 = 0.37 nM 9.43
CHEMBL328773 IC50 = 0.6 nM 9.22
CHEMBL5276568 IC50 = 1.0 nM 9.00
CHEMBL5288816 IC50 = 5.0 nM 8.30
CHEMBL5286303 IC50 = 11.0 nM 7.96
CHEMBL5275025 IC50 = 20.0 nM 7.70
CHEMBL289302 IC50 = 37.0 nM 7.43
CHEMBL5276439 IC50 = 120.0 nM 6.92
CHEMBL5280712 IC50 = 160.0 nM 6.80
CHEMBL5276077 IC50 = 250.0 nM 6.60
CHEMBL5286776 IC50 = 270.0 nM 6.57
CHEMBL5266332 IC50 = 1000.0 nM 6.00
CHEMBL5285866 IC50 = 100000.0 nM 4.00
CHEMBL5265851 IC50 = 100000.0 nM 4.00
CHEMBL308283 IC50 = 2900000.0 nM -