Assay Detail

CHEMBL5258104

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Functional

Antileishmanial activity against Leishmania amazonensis amastigotes assessed as parasite growth inhibition

ChEMBL ↗

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Target

Leishmania amazonensis (CHEMBL612877) ↗

Open DB target context

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Leishmania amazonensis (CHEMBL612877) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Leishmania amazonensis

CHEMBL612877

Anchored from Assay target.

Protein identity Leishmania amazonensis

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Leishmania amazonensis
Confidence	1 — Organism
Curated By	Autocuration

Target

Leishmania amazonensis (CHEMBL612877) ↗

Type	ORGANISM
Organism	Leishmania amazonensis

Publication

Active Natural Product Scaffolds against Trypanosomatid Parasites: A Review.

Cockram PE, Smith TK.
J Nat Prod (2018) 81 : 2138 -2154
PubMed 30234295 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	5.40	5.40

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL434750	ERGOSTEROL PEROXIDE	—	1	5.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL434750	ERGOSTEROL PEROXIDE	EC50	=	4000.0	nM	5.40