Assay Detail
Binding
CHEMBL5258381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using PGC-1alpha as coactivator peptide by isothermal titration calorimetry analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ligand Screening System for the RXRα Heterodimer Using the Fluorescence RXR Agonist CU-6PMN.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.33 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146901 | — | — | 1 | 6.55 |
| CHEMBL1688383 | — | — | 1 | 6.47 |
| CHEMBL4449685 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146901 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL1688383 | — | Kd | = | 340.0 | nM | 6.47 |
| CHEMBL4449685 | — | Kd | = | 1110.0 | nM | 5.96 |