Assay Detail
Binding
CHEMBL5258680
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of human Kir6.2/SUR1 channel outward current expressed in HEK293 cells at -70 mV holding potential by EPC9 patch-clamp amplifier based assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 6.35 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135191 | TIFENAZOXIDE | 2.0 | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135191 | TIFENAZOXIDE | EC50 | = | 450.0 | nM | 6.35 |