Assay Detail
Functional
CHEMBL5259046
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Antiviral activity against HCMV US3-6-EGFP-HCMV-AD169 infected in MRC5 cells assessed as inhibition of viral cytopathic effect incubated for 4 days by fluorescence based HTS assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.87 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL233612 | — | — | 1 | 6.77 |
| CHEMBL5283333 | — | — | 1 | 6.60 |
| CHEMBL5282825 | — | — | 1 | 6.41 |
| CHEMBL5279349 | — | — | 1 | 6.14 |
| CHEMBL5277680 | — | — | 1 | 6.12 |
| CHEMBL1097364 | — | — | 1 | 6.09 |
| CHEMBL5291487 | — | — | 1 | 6.08 |
| CHEMBL5268498 | — | — | 1 | 6.07 |
| CHEMBL5290251 | — | — | 1 | 6.01 |
| CHEMBL5286319 | — | — | 1 | 5.80 |
| CHEMBL5272594 | — | — | 1 | 5.75 |
| CHEMBL440033 | — | — | 1 | 5.46 |
| CHEMBL5274361 | — | — | 1 | 5.37 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.00 |
| CHEMBL1241951 | LETERMOVIR | 4.0 | 1 | 4.44 |
| CHEMBL5267981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL233612 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5283333 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5282825 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5279349 | — | EC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5277680 | — | EC50 | = | 760.0 | nM | 6.12 |
| CHEMBL1097364 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5291487 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5268498 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5290251 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5286319 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5272594 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL440033 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5274361 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL182 | GANCICLOVIR | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1241951 | LETERMOVIR | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5267981 | — | EC50 | > | 40000.0 | nM | - |