Assay Detail
Binding
CHEMBL5259051
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Inhibition of HCMV DNA polymerase incubated for 10 mins in presence of dNTP by fluorescence based assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human betaherpesvirus 5 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.08 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274361 | — | — | 1 | 6.77 |
| CHEMBL1097364 | — | — | 1 | 6.52 |
| CHEMBL5286319 | — | — | 1 | 6.38 |
| CHEMBL5268498 | — | — | 1 | 6.32 |
| CHEMBL5279349 | — | — | 1 | 6.21 |
| CHEMBL5291487 | — | — | 1 | 6.19 |
| CHEMBL5267981 | — | — | 1 | 6.14 |
| CHEMBL5283333 | — | — | 1 | 5.85 |
| CHEMBL5290251 | — | — | 1 | 5.66 |
| CHEMBL5272594 | — | — | 1 | 5.50 |
| CHEMBL440033 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274361 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1097364 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5286319 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5268498 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5279349 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5291487 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5267981 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5283333 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5290251 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5272594 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL440033 | — | IC50 | = | 5000.0 | nM | 5.30 |