Assay Detail
Functional
CHEMBL5259494
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Antiviral activity against DENV-2 infected in human Huh-7 cells assessed as reduction in virus-induced cytopathic effect measured after 15 to 30 mins by neutral red based analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the <i>Bunyavirales</i> Order.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.73 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273609 | — | — | 1 | 6.42 |
| CHEMBL5276564 | — | — | 1 | 5.96 |
| CHEMBL1236524 | GALIDESIVIR | 2.0 | 1 | 4.80 |
| CHEMBL5275463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273609 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5276564 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1236524 | GALIDESIVIR | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL5275463 | — | EC50 | > | 100000.0 | nM | - |