Assay Detail
Binding
CHEMBL5259683
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Inhibition of ALK (unknown origin) pre-incubated for 10 mins followed by substrate addition measured after 60 mins in presence of ATP by mobility shifting assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of sulfonamide derivatives targeting EGFR<sup>790M/L858R</sup> mutations and ALK rearrangement as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.34 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284780 | — | — | 1 | 8.48 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284780 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 6.45 | nM | 8.19 |