Assay Detail
Toxicity
CHEMBL5259703
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Cytotoxicity against human HK-2 cells assessed as inhibition of cell growth measured after 48 to 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HK-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of sulfonamide derivatives targeting EGFR<sup>790M/L858R</sup> mutations and ALK rearrangement as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.57 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 5.62 |
| CHEMBL2403108 | CERITINIB | 4.0 | 1 | 5.60 |
| CHEMBL5284780 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 2399.0 | nM | 5.62 |
| CHEMBL2403108 | CERITINIB | IC50 | = | 2512.0 | nM | 5.60 |
| CHEMBL5284780 | — | IC50 | = | 3303.0 | nM | 5.48 |