Assay Detail
Binding
CHEMBL5259986
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Inhibition of Bacillus cereus beta-lactamase II
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus cereus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis of novel ciprofloxacin-avibactam conjugates for the development of second-generation non-β-lactam-β-lactamase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.38 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282842 | — | — | 1 | 8.77 |
| CHEMBL5283162 | — | — | 1 | 7.24 |
| CHEMBL1689063 | AVIBACTAM | 4.0 | 1 | 6.85 |
| CHEMBL5266921 | — | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282842 | — | IC50 | = | 1.69 | nM | 8.77 |
| CHEMBL5283162 | — | IC50 | = | 57.37 | nM | 7.24 |
| CHEMBL1689063 | AVIBACTAM | IC50 | = | 141.08 | nM | 6.85 |
| CHEMBL5266921 | — | IC50 | = | 226.46 | nM | 6.64 |