Assay Detail
Functional
CHEMBL5260166
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Antiproliferative activity against human MV4-11 cells incubated for 72 hrs by Celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of pyrido[4,3-d]pyrimidinone derivatives as novel Wee1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.96 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 7.02 |
| CHEMBL5287491 | — | — | 1 | 6.18 |
| CHEMBL5268364 | — | — | 1 | 6.12 |
| CHEMBL5270868 | — | — | 1 | 6.10 |
| CHEMBL5285904 | — | — | 1 | 6.06 |
| CHEMBL5291088 | — | — | 1 | 6.06 |
| CHEMBL5274135 | — | — | 1 | 5.99 |
| CHEMBL5280543 | — | — | 1 | 5.97 |
| CHEMBL5282089 | — | — | 1 | 5.94 |
| CHEMBL5284507 | — | — | 1 | 5.91 |
| CHEMBL5269748 | — | — | 1 | 5.88 |
| CHEMBL5283512 | — | — | 1 | 5.83 |
| CHEMBL5269331 | — | — | 1 | 5.75 |
| CHEMBL5288846 | — | — | 1 | 5.69 |
| CHEMBL5289322 | — | — | 1 | 5.61 |
| CHEMBL5283522 | — | — | 1 | 5.57 |
| CHEMBL5266280 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1976040 | ADAVOSERTIB | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL5287491 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5268364 | — | IC50 | = | 763.0 | nM | 6.12 |
| CHEMBL5270868 | — | IC50 | = | 791.0 | nM | 6.10 |
| CHEMBL5285904 | — | IC50 | = | 863.0 | nM | 6.06 |
| CHEMBL5291088 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL5274135 | — | IC50 | = | 1013.0 | nM | 5.99 |
| CHEMBL5280543 | — | IC50 | = | 1073.0 | nM | 5.97 |
| CHEMBL5282089 | — | IC50 | = | 1157.0 | nM | 5.94 |
| CHEMBL5284507 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5269748 | — | IC50 | = | 1326.0 | nM | 5.88 |
| CHEMBL5283512 | — | IC50 | = | 1461.0 | nM | 5.83 |
| CHEMBL5269331 | — | IC50 | = | 1759.0 | nM | 5.75 |
| CHEMBL5288846 | — | IC50 | = | 2048.0 | nM | 5.69 |
| CHEMBL5289322 | — | IC50 | = | 2473.0 | nM | 5.61 |
| CHEMBL5283522 | — | IC50 | = | 2676.0 | nM | 5.57 |
| CHEMBL5266280 | — | IC50 | = | 2690.0 | nM | 5.57 |