Assay Detail
Functional
CHEMBL5260309
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Upregulation of HO-1 expression in human HRMC cells incubated for 18 hrs by ELISA assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HRMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Methyl and Fluorine Effects in Novel Orally Bioavailable Keap1-Nrf2 PPI Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.71 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5284493 | — | — | 1 | 5.70 |
| CHEMBL2381968 | — | — | 1 | 4.98 |
| CHEMBL5278346 | — | — | 1 | 4.44 |
| CHEMBL5284304 | — | — | 1 | 4.25 |
| CHEMBL5289954 | — | — | 1 | 4.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5284493 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2381968 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL5278346 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL5284304 | — | IC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL5289954 | — | IC50 | = | 66000.0 | nM | 4.18 |