Assay Detail
Toxicity
CHEMBL5260330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by fluorescence polarization assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.16 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282278 | — | — | 1 | 7.92 |
| CHEMBL5267582 | — | — | 1 | 7.62 |
| CHEMBL5270277 | — | — | 1 | 7.38 |
| CHEMBL5281311 | — | — | 1 | 7.24 |
| CHEMBL5278658 | — | — | 1 | 6.97 |
| CHEMBL5275479 | — | — | 1 | 6.96 |
| CHEMBL5291336 | — | — | 1 | 6.63 |
| CHEMBL5290513 | — | — | 1 | 6.60 |
| CHEMBL5290180 | — | — | 1 | 6.41 |
| CHEMBL5288787 | — | — | 1 | 6.11 |
| CHEMBL5275370 | — | — | 1 | 5.78 |
| CHEMBL4752026 | — | — | 1 | 5.47 |
| CHEMBL5286868 | — | — | 1 | 5.30 |
| CHEMBL5283063 | — | — | 1 | 5.27 |
| CHEMBL5277819 | — | — | 1 | 5.25 |
| CHEMBL5271919 | — | — | 1 | 5.23 |
| CHEMBL5273026 | — | — | 1 | 5.05 |
| CHEMBL5272403 | — | — | 1 | 4.91 |
| CHEMBL5289856 | — | — | 1 | 4.87 |
| CHEMBL5285837 | — | — | 1 | - |
| CHEMBL5270851 | — | — | 1 | - |
| CHEMBL5268577 | — | — | 1 | - |
| CHEMBL5275866 | — | — | 1 | - |
| CHEMBL5278669 | — | — | 1 | - |
| CHEMBL5287742 | — | — | 1 | - |
| CHEMBL5290261 | — | — | 1 | - |
| CHEMBL5266654 | — | — | 1 | - |
| CHEMBL5270502 | — | — | 1 | - |
| CHEMBL5275625 | — | — | 1 | - |
| CHEMBL5290376 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282278 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5267582 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL5270277 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5281311 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5278658 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL5275479 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5291336 | — | IC50 | = | 235.0 | nM | 6.63 |
| CHEMBL5290513 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5290180 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL5288787 | — | IC50 | = | 769.0 | nM | 6.11 |
| CHEMBL5275370 | — | IC50 | = | 1661.0 | nM | 5.78 |
| CHEMBL4752026 | — | IC50 | = | 3348.0 | nM | 5.47 |
| CHEMBL5286868 | — | IC50 | = | 5057.0 | nM | 5.30 |
| CHEMBL5283063 | — | IC50 | = | 5352.0 | nM | 5.27 |
| CHEMBL5277819 | — | IC50 | = | 5561.0 | nM | 5.25 |
| CHEMBL5271919 | — | IC50 | = | 5875.0 | nM | 5.23 |
| CHEMBL5273026 | — | IC50 | = | 8957.0 | nM | 5.05 |
| CHEMBL5272403 | — | IC50 | = | 12322.0 | nM | 4.91 |
| CHEMBL5289856 | — | IC50 | = | 13493.0 | nM | 4.87 |
| CHEMBL5285837 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5270851 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5268577 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5275866 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5278669 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5287742 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5290261 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL5266654 | — | IC50 | - | — | - | |
| CHEMBL5270502 | — | IC50 | - | — | - | |
| CHEMBL5275625 | — | IC50 | - | — | - | |
| CHEMBL5290376 | — | IC50 | - | — | - |