Assay Detail
Functional
CHEMBL5260331
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Antiproliferative activity against human KYSE520 cells assessed as inhibition of cell proliferation incubated for 96 hrs by CellTiter-Glo reagent based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KYSE-520 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5290261 | — | — | 1 | 6.78 |
| CHEMBL5272403 | — | — | 1 | 6.74 |
| CHEMBL5285837 | — | — | 1 | 6.64 |
| CHEMBL4752026 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5290261 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL5272403 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL5285837 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL4752026 | — | IC50 | = | 4550.0 | nM | 5.34 |