Assay Detail
Binding
CHEMBL5260348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human TLR7 expressed in human PBMC cells preincubated for 1 hr followed by GS-986 stimulation measured after 6 hrs by electrochemiluminescence immunoassay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Thienopyrrole Compounds for Treating Autoimmune Diseases and Inflammatory Conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.69 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5266091 | — | — | 1 | 10.15 |
| CHEMBL5267703 | — | — | 1 | 9.96 |
| CHEMBL5277999 | — | — | 1 | 9.62 |
| CHEMBL5273537 | — | — | 1 | 9.57 |
| CHEMBL5291249 | — | — | 1 | 9.48 |
| CHEMBL5272936 | — | — | 1 | 9.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5266091 | — | EC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5267703 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5277999 | — | EC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5273537 | — | EC50 | = | 0.27 | nM | 9.57 |
| CHEMBL5291249 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL5272936 | — | EC50 | = | 0.46 | nM | 9.34 |