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Assay Detail

CHEMBL5260357

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Toxicity
Cytotoxicity against human C3PV cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Homo sapiens
Cell Type C3PV
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis of Artesunic Acid-Coumarin Hybrids as Potential Antimelanoma Agents.
Zippilli C, Filippi S, Cesarini S, Bizzarri BM, Conigliaro P, De Marchi E, Botta L, Saladino R.
ACS Med Chem Lett (2023) 14 : 599 -605
PubMed 37197457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.37 6.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5280206 1 6.68
CHEMBL301141 4-HYDROXYCOUMARINS 1 6.22
CHEMBL5267387 1 6.18
CHEMBL71851 SCOPOLETIN 1 5.80
CHEMBL5282997 1 5.78
CHEMBL104679 1 5.60
CHEMBL243263 6-HYDROXYCOUMARIN 1 5.53
CHEMBL5288863 1 5.52
CHEMBL5278693 1 5.25
CHEMBL12208 HYMECROMONE 2.0 1 5.16
CHEMBL150372 3-HYDROXYCOUMARIN 1 4.90
CHEMBL51628 UMBELLIFERONE 1 4.68
CHEMBL244743 ESCULETIN 1 4.59
CHEMBL1301731 1 4.56
CHEMBL428647 PACLITAXEL 4.0 1 4.10
CHEMBL5281422 1 -
CHEMBL5282348 1 -
CHEMBL5276359 1 -
CHEMBL5265840 1 -
CHEMBL5288167 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5280206 IC50 = 210.0 nM 6.68
CHEMBL301141 4-HYDROXYCOUMARINS IC50 = 600.0 nM 6.22
CHEMBL5267387 IC50 = 660.0 nM 6.18
CHEMBL71851 SCOPOLETIN IC50 = 1600.0 nM 5.80
CHEMBL5282997 IC50 = 1680.0 nM 5.78
CHEMBL104679 IC50 = 2500.0 nM 5.60
CHEMBL243263 6-HYDROXYCOUMARIN IC50 = 2950.0 nM 5.53
CHEMBL5288863 IC50 = 3050.0 nM 5.52
CHEMBL5278693 IC50 = 5640.0 nM 5.25
CHEMBL12208 HYMECROMONE IC50 = 7000.0 nM 5.16
CHEMBL150372 3-HYDROXYCOUMARIN IC50 = 12530.0 nM 4.90
CHEMBL51628 UMBELLIFERONE IC50 = 20880.0 nM 4.68
CHEMBL244743 ESCULETIN IC50 = 25840.0 nM 4.59
CHEMBL1301731 IC50 = 27400.0 nM 4.56
CHEMBL428647 PACLITAXEL IC50 = 78880.0 nM 4.10
CHEMBL5281422 IC50 = 1060000.0 nM -
CHEMBL5282348 IC50 = 321400.0 nM -
CHEMBL5276359 IC50 = 132200.0 nM -
CHEMBL5265840 IC50 = 216100.0 nM -
CHEMBL5288167 IC50 = 686100.0 nM -