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Assay Detail

CHEMBL5260358

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human SK-MEL3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL3
Confidence 1 — Organism
Curated By Autocuration

Target

SK-MEL3 (CHEMBL614920)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of Artesunic Acid-Coumarin Hybrids as Potential Antimelanoma Agents.
Zippilli C, Filippi S, Cesarini S, Bizzarri BM, Conigliaro P, De Marchi E, Botta L, Saladino R.
ACS Med Chem Lett (2023) 14 : 599 -605
PubMed 37197457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.87 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5276359 1 7.82
CHEMBL5265840 1 7.30
CHEMBL104679 1 6.24
CHEMBL1301731 1 6.03
CHEMBL5278693 1 6.00
CHEMBL5280206 1 5.89
CHEMBL71851 SCOPOLETIN 1 5.82
CHEMBL12208 HYMECROMONE 2.0 1 5.80
CHEMBL244743 ESCULETIN 1 5.77
CHEMBL243263 6-HYDROXYCOUMARIN 1 5.73
CHEMBL5288167 1 5.72
CHEMBL51628 UMBELLIFERONE 1 5.68
CHEMBL301141 4-HYDROXYCOUMARINS 1 5.68
CHEMBL5267387 1 5.58
CHEMBL5282348 1 5.57
CHEMBL5282997 1 5.46
CHEMBL5281422 1 5.44
CHEMBL5288863 1 5.39
CHEMBL428647 PACLITAXEL 4.0 1 5.33
CHEMBL150372 3-HYDROXYCOUMARIN 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5276359 IC50 = 15.0 nM 7.82
CHEMBL5265840 IC50 = 50.0 nM 7.30
CHEMBL104679 IC50 = 580.0 nM 6.24
CHEMBL1301731 IC50 = 930.0 nM 6.03
CHEMBL5278693 IC50 = 1000.0 nM 6.00
CHEMBL5280206 IC50 = 1300.0 nM 5.89
CHEMBL71851 SCOPOLETIN IC50 = 1500.0 nM 5.82
CHEMBL12208 HYMECROMONE IC50 = 1600.0 nM 5.80
CHEMBL244743 ESCULETIN IC50 = 1700.0 nM 5.77
CHEMBL243263 6-HYDROXYCOUMARIN IC50 = 1850.0 nM 5.73
CHEMBL5288167 IC50 = 1900.0 nM 5.72
CHEMBL51628 UMBELLIFERONE IC50 = 2100.0 nM 5.68
CHEMBL301141 4-HYDROXYCOUMARINS IC50 = 2100.0 nM 5.68
CHEMBL5267387 IC50 = 2600.0 nM 5.58
CHEMBL5282348 IC50 = 2700.0 nM 5.57
CHEMBL5282997 IC50 = 3430.0 nM 5.46
CHEMBL5281422 IC50 = 3600.0 nM 5.44
CHEMBL5288863 IC50 = 4100.0 nM 5.39
CHEMBL428647 PACLITAXEL IC50 = 4730.0 nM 5.33
CHEMBL150372 3-HYDROXYCOUMARIN IC50 = 6800.0 nM 5.17