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Assay Detail

CHEMBL5260359

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-MEL-28
Confidence 1 — Organism
Curated By Autocuration

Target

SK-MEL-28 (CHEMBL614919)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis of Artesunic Acid-Coumarin Hybrids as Potential Antimelanoma Agents.
Zippilli C, Filippi S, Cesarini S, Bizzarri BM, Conigliaro P, De Marchi E, Botta L, Saladino R.
ACS Med Chem Lett (2023) 14 : 599 -605
PubMed 37197457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.55 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL243263 6-HYDROXYCOUMARIN 1 6.35
CHEMBL51628 UMBELLIFERONE 1 6.32
CHEMBL12208 HYMECROMONE 2.0 1 6.24
CHEMBL244743 ESCULETIN 1 6.02
CHEMBL1301731 1 6.01
CHEMBL5282997 1 6.01
CHEMBL428647 PACLITAXEL 4.0 1 5.97
CHEMBL104679 1 5.96
CHEMBL150372 3-HYDROXYCOUMARIN 1 5.92
CHEMBL301141 4-HYDROXYCOUMARINS 1 5.89
CHEMBL5265840 1 5.66
CHEMBL71851 SCOPOLETIN 1 5.46
CHEMBL5281422 1 5.17
CHEMBL5267387 1 4.87
CHEMBL5278693 1 4.42
CHEMBL5282348 1 4.14
CHEMBL5288167 1 4.01
CHEMBL5288863 1 -
CHEMBL5280206 1 -
CHEMBL5276359 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL243263 6-HYDROXYCOUMARIN IC50 = 450.0 nM 6.35
CHEMBL51628 UMBELLIFERONE IC50 = 480.0 nM 6.32
CHEMBL12208 HYMECROMONE IC50 = 580.0 nM 6.24
CHEMBL244743 ESCULETIN IC50 = 960.0 nM 6.02
CHEMBL1301731 IC50 = 980.0 nM 6.01
CHEMBL5282997 IC50 = 980.0 nM 6.01
CHEMBL428647 PACLITAXEL IC50 = 1070.0 nM 5.97
CHEMBL104679 IC50 = 1100.0 nM 5.96
CHEMBL150372 3-HYDROXYCOUMARIN IC50 = 1200.0 nM 5.92
CHEMBL301141 4-HYDROXYCOUMARINS IC50 = 1300.0 nM 5.89
CHEMBL5265840 IC50 = 2200.0 nM 5.66
CHEMBL71851 SCOPOLETIN IC50 = 3430.0 nM 5.46
CHEMBL5281422 IC50 = 6840.0 nM 5.17
CHEMBL5267387 IC50 = 13450.0 nM 4.87
CHEMBL5278693 IC50 = 37980.0 nM 4.42
CHEMBL5282348 IC50 = 72820.0 nM 4.14
CHEMBL5288167 IC50 = 97910.0 nM 4.01
CHEMBL5288863 IC50 = 132000.0 nM -
CHEMBL5280206 IC50 = 1090000.0 nM -
CHEMBL5276359 IC50 = 576000.0 nM -