Assay Detail
Binding
CHEMBL5260511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human AHR in HEK293 cells assessed as nuclear translocation over cytosol incubated for 45 mins by Hoechst staining based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Subcellular | Cytosol |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel AHR Agonists for Treating Psoriasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 9.66 | 9.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270440 | — | — | 1 | 9.86 |
| CHEMBL5266782 | — | — | 1 | 9.79 |
| CHEMBL5265853 | — | — | 1 | 9.72 |
| CHEMBL5284079 | — | — | 1 | 9.56 |
| CHEMBL5274394 | — | — | 1 | 9.53 |
| CHEMBL5270280 | — | — | 1 | 9.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270440 | — | EC50 | = | 0.137 | nM | 9.86 |
| CHEMBL5266782 | — | EC50 | = | 0.161 | nM | 9.79 |
| CHEMBL5265853 | — | EC50 | = | 0.189 | nM | 9.72 |
| CHEMBL5284079 | — | EC50 | = | 0.275 | nM | 9.56 |
| CHEMBL5274394 | — | EC50 | = | 0.297 | nM | 9.53 |
| CHEMBL5270280 | — | EC50 | = | 0.34 | nM | 9.47 |