Assay Detail
Functional
CHEMBL5260656
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Antiproliferative activity against human LN-229 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiter96 Aqueous One Solution cell proliferation assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LN-229 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Biological evaluation of novel amidino substituted coumarin-benzazole hybrids as promising therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.49 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.00 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.37 |
| CHEMBL5284601 | — | — | 1 | 5.85 |
| CHEMBL5276739 | — | — | 1 | 5.75 |
| CHEMBL5266539 | — | — | 1 | 5.04 |
| CHEMBL5287724 | — | — | 1 | 4.39 |
| CHEMBL5273678 | — | — | 1 | 4.01 |
| CHEMBL5274445 | — | — | 1 | - |
| CHEMBL5286680 | — | — | 1 | - |
| CHEMBL5271525 | — | — | 1 | - |
| CHEMBL5274153 | — | — | 1 | - |
| CHEMBL5289851 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5284601 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5276739 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5266539 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5287724 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL5273678 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL5274445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5286680 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5271525 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5274153 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5289851 | — | IC50 | > | 100000.0 | nM | - |