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Assay Detail

CHEMBL5261109

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to CXCR4 (unknown origin) assessed as inhibition constant
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

C-X-C chemokine receptor type 4 (CHEMBL2107)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural Analysis of Chemokine Receptor-Ligand Interactions.
Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C.
J Med Chem (2017) 60 : 4735 -4779
PubMed 28165741 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 6.59 9.21

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1242211 1 9.21
CHEMBL477121 1 8.00
CHEMBL518924 MAVORIXAFOR 4.0 1 7.64
CHEMBL278054 1 7.08
CHEMBL122226 1 6.77
CHEMBL28967 1 6.75
CHEMBL5284797 1 6.19
CHEMBL277955 1 6.07
CHEMBL478168 1 5.77
CHEMBL127188 1 5.64
CHEMBL2367715 1 5.10
CHEMBL125150 1 4.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1242211 Ki = 0.61 nM 9.21
CHEMBL477121 Ki = 10.0 nM 8.00
CHEMBL518924 MAVORIXAFOR Ki = 23.0 nM 7.64
CHEMBL278054 Ki = 83.0 nM 7.08
CHEMBL122226 Ki = 170.0 nM 6.77
CHEMBL28967 Ki = 180.0 nM 6.75
CHEMBL5284797 Ki = 650.0 nM 6.19
CHEMBL277955 Ki = 850.0 nM 6.07
CHEMBL478168 Ki = 1700.0 nM 5.77
CHEMBL127188 Ki = 2300.0 nM 5.64
CHEMBL2367715 Ki = 8000.0 nM 5.10
CHEMBL125150 Ki = 13000.0 nM 4.89