Assay Detail
Binding
CHEMBL5261111
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Inhibition of CXCR4-Y251A mutant (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Analysis of Chemokine Receptor-Ligand Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.36 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | 4.0 | 1 | 9.70 |
| CHEMBL5290321 | — | — | 1 | 8.85 |
| CHEMBL82301 | VICRIVIROC | 3.0 | 1 | 8.52 |
| CHEMBL1255794 | APLAVIROC | 3.0 | 1 | 8.24 |
| CHEMBL1200019 | — | — | 1 | 7.78 |
| CHEMBL41275 | — | — | 1 | 7.72 |
| CHEMBL207004 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL256907 | MARAVIROC | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5290321 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL82301 | VICRIVIROC | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1255794 | APLAVIROC | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1200019 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL41275 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL207004 | — | IC50 | = | 20.0 | nM | 7.70 |