Assay Detail

CHEMBL5261126

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Binding

Inhibition of human recombinant CCR1

ChEMBL ↗

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Target

C-C chemokine receptor type 1 (CHEMBL2413) ↗

Open DB target context

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C-C chemokine receptor type 1 (CHEMBL2413) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target C-C chemokine receptor type 1

CHEMBL2413

Anchored from Assay target.

Protein identity C-C chemokine receptor type 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

C-C chemokine receptor type 1 (CHEMBL2413) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Structural Analysis of Chemokine Receptor-Ligand Interactions.

Arimont M, Sun SL, Leurs R, Smit M, de Esch IJP, de Graaf C.
J Med Chem (2017) 60 : 4735 -4779
PubMed 28165741 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.00	8.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL232656	BX 471 FREE BASE	2.0	1	8.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL232656	BX 471 FREE BASE	IC50	=	10.0	nM	8.00