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Assay Detail

CHEMBL5261682

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Functional
Cytotoxicity against human KMS-26 cells measured after 8 days
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KMS-26
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.
Crawford TD, Vartanian S, Côté A, Bellon S, Duplessis M, Flynn EM, Hewitt M, Huang HR, Kiefer JR, Murray J, Nasveschuk CG, Pardo E, Romero FA, Sandy P, Tang Y, Taylor AM, Tsui V, Wang J, Wang S, Zawadzke L, Albrecht BK, Magnuson SR, Cochran AG, Stokoe D.
Bioorg Med Chem Lett (2017) 27 : 3534 -3541
PubMed 28606761 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.63 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5270178 1 5.68
CHEMBL5282240 1 5.58

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5270178 IC50 = 2110.0 nM 5.68
CHEMBL5282240 IC50 = 2610.0 nM 5.58