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Assay Detail

CHEMBL5262832

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of FABP3 (unknown origin) by fluorescence polarization assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Fatty acid-binding protein, heart (CHEMBL3344)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Adipocyte fatty acid binding protein 4 (FABP4) inhibitors. A comprehensive systematic review.
Floresta G, Pistarà V, Amata E, Dichiara M, Marrazzo A, Prezzavento O, Rescifina A.
Eur J Med Chem (2017) 138 : 854 -873
PubMed 28738306 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 5 5.05 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL82293 PALMITIC ACID -1.0 1 5.58
CHEMBL184817 1 5.24
CHEMBL363032 1 5.00
CHEMBL364141 1 4.38
CHEMBL185595 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL82293 PALMITIC ACID IC50 = 2600.0 nM 5.58
CHEMBL184817 IC50 = 5700.0 nM 5.24
CHEMBL363032 IC50 = 9900.0 nM 5.00
CHEMBL364141 IC50 = 42000.0 nM 4.38
CHEMBL185595 IC50 < 600.0 nM -