Assay Detail
Functional
CHEMBL5262899
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth under normoxia condition by SRB assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144932 | — | — | 1 | 6.22 |
| CHEMBL145788 | — | — | 1 | 6.22 |
| CHEMBL144407 | — | — | 1 | 6.22 |
| CHEMBL344761 | — | — | 1 | 6.22 |
| CHEMBL144115 | — | — | 1 | 6.22 |
| CHEMBL342956 | — | — | 1 | 6.22 |
| CHEMBL144526 | — | — | 1 | 6.22 |
| CHEMBL144802 | — | — | 1 | 6.22 |
| CHEMBL143167 | — | — | 1 | 6.22 |
| CHEMBL423373 | — | — | 1 | 6.22 |
| CHEMBL50882 | TIRAPAZAMINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144932 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL145788 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144407 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL344761 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144115 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL342956 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144526 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL144802 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL143167 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL423373 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL50882 | TIRAPAZAMINE | IC50 | = | 387000.0 | nM | - |