Assay Detail
Binding
CHEMBL5263012
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Inhibition of Trypanosoma brucei TryR assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Trypanothione reductase (CHEMBL1837) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei brucei |
Publication
Polyamine-based analogs and conjugates as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.35 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86281 | — | — | 1 | 6.22 |
| CHEMBL62048 | — | — | 1 | 5.52 |
| CHEMBL86096 | — | — | 1 | 4.92 |
| CHEMBL81614 | — | — | 1 | 4.72 |
| CHEMBL211029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86281 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL62048 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL86096 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL81614 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL211029 | — | Ki | > | 100000.0 | nM | - |