Assay Detail
Binding
CHEMBL5263127
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Inhibition of Trypanosoma brucei MetRS
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Polyamine-based analogs and conjugates as antikinetoplastid agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.85 | 9.00 |
| Ki | 1 | 8.70 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5274009 | — | — | 1 | 9.00 |
| CHEMBL5287624 | — | — | 1 | 9.00 |
| CHEMBL5272888 | — | — | 1 | 8.70 |
| CHEMBL5288670 | — | — | 2 | 8.70 |
| CHEMBL587208 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5274009 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5287624 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5272888 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5288670 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5288670 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL587208 | — | IC50 | < | 25.0 | nM | - |