Assay Detail
Functional
CHEMBL5263137
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Anticancer activity against human KB cells assessed as inhibition of cell growth
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylpyrimidine coumarin derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.91 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.52 |
| CHEMBL5280294 | — | — | 1 | 5.43 |
| CHEMBL5272170 | — | — | 1 | 5.25 |
| CHEMBL5288791 | — | — | 1 | 5.17 |
| CHEMBL5272341 | — | — | 1 | 5.13 |
| CHEMBL5272458 | — | — | 1 | 4.94 |
| CHEMBL5267879 | — | — | 1 | 4.80 |
| CHEMBL5287988 | — | — | 1 | 4.77 |
| CHEMBL5289403 | — | — | 1 | 4.73 |
| CHEMBL5270093 | — | — | 1 | 4.68 |
| CHEMBL5273293 | — | — | 1 | 4.53 |
| CHEMBL5279003 | — | — | 1 | 4.44 |
| CHEMBL5283808 | — | — | 1 | 4.42 |
| CHEMBL5289870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3040.0 | nM | 5.52 |
| CHEMBL5280294 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL5272170 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL5288791 | — | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL5272341 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL5272458 | — | IC50 | = | 11590.0 | nM | 4.94 |
| CHEMBL5267879 | — | IC50 | = | 15830.0 | nM | 4.80 |
| CHEMBL5287988 | — | IC50 | = | 16990.0 | nM | 4.77 |
| CHEMBL5289403 | — | IC50 | = | 18620.0 | nM | 4.73 |
| CHEMBL5270093 | — | IC50 | = | 20860.0 | nM | 4.68 |
| CHEMBL5273293 | — | IC50 | = | 29720.0 | nM | 4.53 |
| CHEMBL5279003 | — | IC50 | = | 36170.0 | nM | 4.44 |
| CHEMBL5283808 | — | IC50 | = | 38360.0 | nM | 4.42 |
| CHEMBL5289870 | — | IC50 | > | 100000.0 | nM | - |