Assay Detail
Functional
CHEMBL5263138
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human CAL-27 cells assessed as inhibition of cell growth
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CAL-27 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylpyrimidine coumarin derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.14 | 5.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.81 |
| CHEMBL5280294 | — | — | 1 | 5.71 |
| CHEMBL5288791 | — | — | 1 | 5.59 |
| CHEMBL5287988 | — | — | 1 | 5.45 |
| CHEMBL5272341 | — | — | 1 | 5.37 |
| CHEMBL5272458 | — | — | 1 | 5.31 |
| CHEMBL5289403 | — | — | 1 | 5.02 |
| CHEMBL5272170 | — | — | 1 | 5.00 |
| CHEMBL5270093 | — | — | 1 | 4.95 |
| CHEMBL5273293 | — | — | 1 | 4.75 |
| CHEMBL5279003 | — | — | 1 | 4.74 |
| CHEMBL5267879 | — | — | 1 | 4.74 |
| CHEMBL5283808 | — | — | 1 | 4.32 |
| CHEMBL5289870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL5280294 | — | IC50 | = | 1970.0 | nM | 5.71 |
| CHEMBL5288791 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL5287988 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL5272341 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL5272458 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL5289403 | — | IC50 | = | 9630.0 | nM | 5.02 |
| CHEMBL5272170 | — | IC50 | = | 10120.0 | nM | 5.00 |
| CHEMBL5270093 | — | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL5273293 | — | IC50 | = | 17630.0 | nM | 4.75 |
| CHEMBL5279003 | — | IC50 | = | 18340.0 | nM | 4.74 |
| CHEMBL5267879 | — | IC50 | = | 18070.0 | nM | 4.74 |
| CHEMBL5283808 | — | IC50 | = | 47470.0 | nM | 4.32 |
| CHEMBL5289870 | — | IC50 | > | 100000.0 | nM | - |