Assay Detail
Binding
CHEMBL5263147
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of telomerase activity in human CNE-2 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CNE-2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 2-phenylpyrimidine coumarin derivatives as anticancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.21 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5280294 | — | — | 1 | 6.09 |
| CHEMBL284328 | HOMIDIUM BROMIDE | 2.0 | 1 | 5.67 |
| CHEMBL5288791 | — | — | 1 | 5.50 |
| CHEMBL5273293 | — | — | 1 | 5.20 |
| CHEMBL5272170 | — | — | 1 | 5.13 |
| CHEMBL5287988 | — | — | 1 | 4.68 |
| CHEMBL5289870 | — | — | 1 | 4.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5280294 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL284328 | HOMIDIUM BROMIDE | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5288791 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL5273293 | — | IC50 | = | 6320.0 | nM | 5.20 |
| CHEMBL5272170 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL5287988 | — | IC50 | = | 21070.0 | nM | 4.68 |
| CHEMBL5289870 | — | IC50 | = | 58640.0 | nM | 4.23 |