Assay Detail
Binding
CHEMBL5263271
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Inhibition of P-gp (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.86 | 6.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26635 | — | — | 1 | 6.98 |
| CHEMBL5288378 | — | — | 1 | 6.31 |
| CHEMBL168831 | — | — | 1 | 5.88 |
| CHEMBL356478 | — | — | 1 | 5.88 |
| CHEMBL5277917 | — | — | 1 | 5.67 |
| CHEMBL5274754 | — | — | 1 | 5.48 |
| CHEMBL5283433 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26635 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL5288378 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL168831 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL356478 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5277917 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5274754 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL5283433 | — | IC50 | = | 14000.0 | nM | 4.85 |