Assay Detail
Binding
CHEMBL5263274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of P-gp (unknown origin) expressed in human A2780 ADR cells by calcein AM accumulation assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 ADR |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
9-Deazapurines as Broad-Spectrum Inhibitors of the ABC Transport Proteins P-Glycoprotein, Multidrug Resistance-Associated Protein 1, and Breast Cancer Resistance Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.23 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2158554 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2158554 | — | IC50 | = | 5850.0 | nM | 5.23 |