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Assay Detail

CHEMBL5263430

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2093867)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Enzyme inhibitory activities an insight into the structure-Activity relationship of biscoumarin derivatives.
Faisal M, Saeed A, Shahzad D, Fattah TA, Lal B, Channar PA, Mahar J, Saeed S, Mahesar PA, Larik FA.
Eur J Med Chem (2017) 141 : 386 -403
PubMed 29032032 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.60 4.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL244948 DAPHNETIN -1.0 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL244948 DAPHNETIN IC50 = 25010.0 nM 4.60