Assay Detail
Functional
CHEMBL5263706
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Antiproliferative activity against human MKN-45 cells assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MKN-45 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in the discovery of small molecule c-Met Kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.04 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5273665 | — | — | 1 | 8.00 |
| CHEMBL4576664 | — | — | 1 | 7.80 |
| CHEMBL3797911 | — | — | 1 | 7.68 |
| CHEMBL3949465 | — | — | 1 | 7.52 |
| CHEMBL5282538 | — | — | 1 | 7.22 |
| CHEMBL5268219 | — | — | 1 | 6.41 |
| CHEMBL5285411 | — | — | 1 | 6.35 |
| CHEMBL5287421 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5273665 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4576664 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3797911 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL3949465 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5282538 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5268219 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5285411 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5287421 | — | IC50 | = | 4300.0 | nM | 5.37 |