Assay Detail
Binding
CHEMBL5263772
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Positive allosteric modulation of human GABAA alpha2beta1gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gamma-aminobutyric acid receptor subunit alpha-2/beta-1/gamma-2 (CHEMBL5291949) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Breakthroughs in neuroactive steroid drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.85 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1568698 | GANAXOLONE | 4.0 | 1 | 7.00 |
| CHEMBL5281882 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1568698 | GANAXOLONE | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5281882 | — | EC50 | = | 200.0 | nM | 6.70 |