Assay Detail
Binding
CHEMBL5264014
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Binding affinity to AT2 in rat brain
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of quinazolines: Pharmacological significance and recent developments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.59 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL35324 | — | — | 1 | 10.22 |
| CHEMBL34082 | — | — | 1 | 9.66 |
| CHEMBL35638 | — | — | 1 | 9.66 |
| CHEMBL285433 | — | — | 1 | 9.66 |
| CHEMBL285432 | — | — | 1 | 9.66 |
| CHEMBL290669 | — | — | 1 | 9.66 |
| CHEMBL289472 | — | — | 1 | 9.66 |
| CHEMBL290768 | — | — | 1 | 9.66 |
| CHEMBL5278845 | — | — | 1 | 9.34 |
| CHEMBL276853 | — | — | 1 | 9.34 |
| CHEMBL302102 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL35324 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL34082 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL35638 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL285433 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL285432 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL290669 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL289472 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL290768 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL5278845 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL276853 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL302102 | — | IC50 | = | 1.0 | nM | 9.00 |