Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5264017

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of rat adrenal cortex angiotensin II
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Adrenal cortex
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Angiotensinogen (CHEMBL5291508)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

An overview of quinazolines: Pharmacological significance and recent developments.
Alagarsamy V, Chitra K, Saravanan G, Solomon VR, Sulthana MT, Narendhar B.
Eur J Med Chem (2018) 151 : 628 -685
PubMed 29656203 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.44 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL14748 1 8.30
CHEMBL15225 1 8.30
CHEMBL275875 CL-329167 1 7.75
CHEMBL15118 1 7.75
CHEMBL15154 1 7.75
CHEMBL415982 1 7.30
CHEMBL277333 1 7.05
CHEMBL15484 1 6.27
CHEMBL279129 1 6.27
CHEMBL15284 1 5.96
CHEMBL5274876 1 4.92
CHEMBL278235 1 4.89
CHEMBL14950 1 4.85
CHEMBL15470 1 4.85
CHEMBL279602 1 4.35
CHEMBL274466 1 -
CHEMBL416714 1 -
CHEMBL14951 1 -
CHEMBL415983 1 -
CHEMBL15283 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL14748 IC50 = 5.0 nM 8.30
CHEMBL15225 IC50 = 5.0 nM 8.30
CHEMBL275875 CL-329167 IC50 = 18.0 nM 7.75
CHEMBL15118 IC50 = 18.0 nM 7.75
CHEMBL15154 IC50 = 18.0 nM 7.75
CHEMBL415982 IC50 = 50.0 nM 7.30
CHEMBL277333 IC50 = 90.0 nM 7.05
CHEMBL15484 IC50 = 540.0 nM 6.27
CHEMBL279129 IC50 = 540.0 nM 6.27
CHEMBL15284 IC50 = 1100.0 nM 5.96
CHEMBL5274876 IC50 = 12000.0 nM 4.92
CHEMBL278235 IC50 = 13000.0 nM 4.89
CHEMBL14950 IC50 = 14000.0 nM 4.85
CHEMBL15470 IC50 = 14000.0 nM 4.85
CHEMBL279602 IC50 = 45000.0 nM 4.35
CHEMBL274466 IC50 > 1000.0 nM -
CHEMBL416714 IC50 > 1000.0 nM -
CHEMBL14951 IC50 > 1000.0 nM -
CHEMBL415983 IC50 > 1000.0 nM -
CHEMBL15283 IC50 > 1000.0 nM -