Assay Detail
Binding
CHEMBL5264025
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Inhibition of 5-HT2A (unknown origin) assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An overview of quinazolines: Pharmacological significance and recent developments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.49 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 8.83 |
| CHEMBL5267849 | — | — | 1 | 8.58 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 8.43 |
| CHEMBL5290270 | — | — | 1 | 8.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267777 | RITANSERIN | Ki | = | 1.479 | nM | 8.83 |
| CHEMBL5267849 | — | Ki | = | 2.63 | nM | 8.58 |
| CHEMBL51 | KETANSERIN | Ki | = | 3.715 | nM | 8.43 |
| CHEMBL5290270 | — | Ki | = | 7.586 | nM | 8.12 |