Assay Detail
Binding
CHEMBL5264104
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Inhibition of human RORgamma by TR-FRET assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Combating Autoimmune Diseases With Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ or RORc) Inhibitors: Hits and Misses.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270756 | — | — | 1 | 8.70 |
| CHEMBL4172726 | — | — | 1 | 7.80 |
| CHEMBL5287608 | — | — | 1 | 7.80 |
| CHEMBL5205826 | — | — | 1 | 7.40 |
| CHEMBL4864604 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270756 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4172726 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5287608 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL5205826 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4864604 | — | IC50 | = | 40.0 | nM | 7.40 |