Assay Detail
Binding
CHEMBL5265488
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Inhibition of ACK1 R806Q mutant in mouse BaF3 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Small Molecules Targeting Activated Cdc42-Associated Kinase 1 (ACK1/TNK2) for the Treatment of Cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.65 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 8.89 |
| CHEMBL4641789 | — | — | 1 | 7.11 |
| CHEMBL1672987 | — | — | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4641789 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1672987 | — | IC50 | = | 113.0 | nM | 6.95 |