Assay Detail
Toxicity
CHEMBL5265557
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Cytotoxicity against human HUVEC cells assessed as cell growth inhibition incubated for 72 hrs by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of pyrazolo[3,4-<i>b</i>]pyridine derivatives as TRK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.43 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5282566 | — | — | 1 | 4.43 |
| CHEMBL3889654 | LAROTRECTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5282566 | — | IC50 | = | 36690.0 | nM | 4.43 |
| CHEMBL3889654 | LAROTRECTINIB | IC50 | - | — | - |