Assay Detail
Binding
CHEMBL5316640
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]alpha-Bungarotoxin from human alpha7 nAChR expressed in human SH-SY5Y cell membrane assessed as inhibition constant by direct gamma counting method
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SH-SY5Y |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL2492) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Subnanomolar Affinity and Selective Antagonism at α7 Nicotinic Receptor by Combined Modifications of 2-Triethylammonium Ethyl Ether of 4-Stilbenol (MG624).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 33 | 6.44 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5393773 | — | — | 1 | 9.00 |
| CHEMBL5417751 | — | — | 1 | 7.72 |
| CHEMBL5178473 | — | — | 1 | 7.64 |
| CHEMBL5433741 | — | — | 1 | 7.47 |
| CHEMBL5423336 | — | — | 1 | 7.09 |
| CHEMBL1257065 | STILONIUM IODIDE | 2.0 | 1 | 6.98 |
| CHEMBL5435415 | — | — | 1 | 6.89 |
| CHEMBL5416962 | — | — | 1 | 6.78 |
| CHEMBL5409285 | — | — | 1 | 6.74 |
| CHEMBL4287656 | — | — | 1 | 6.72 |
| CHEMBL5403618 | — | — | 1 | 6.62 |
| CHEMBL5436520 | — | — | 1 | 6.60 |
| CHEMBL5435510 | — | — | 1 | 6.54 |
| CHEMBL5407945 | — | — | 1 | 6.47 |
| CHEMBL5395819 | — | — | 1 | 6.45 |
| CHEMBL5400651 | — | — | 1 | 6.35 |
| CHEMBL5396300 | — | — | 1 | 6.28 |
| CHEMBL5408237 | — | — | 1 | 6.28 |
| CHEMBL5418191 | — | — | 1 | 6.24 |
| CHEMBL5415738 | — | — | 1 | 6.21 |
| CHEMBL5415788 | — | — | 1 | 6.18 |
| CHEMBL5428774 | — | — | 1 | 6.14 |
| CHEMBL5396579 | — | — | 1 | 6.06 |
| CHEMBL5415255 | — | — | 1 | 6.00 |
| CHEMBL5412463 | — | — | 1 | 6.00 |
| CHEMBL5425014 | — | — | 1 | 5.99 |
| CHEMBL5415576 | — | — | 1 | 5.88 |
| CHEMBL5416363 | — | — | 1 | 5.87 |
| CHEMBL5406306 | — | — | 1 | 5.82 |
| CHEMBL5399641 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5393773 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL5417751 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL5178473 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL5433741 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL5423336 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL1257065 | STILONIUM IODIDE | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL5435415 | — | Ki | = | 129.0 | nM | 6.89 |
| CHEMBL5416962 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL5409285 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL4287656 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL5403618 | — | Ki | = | 242.0 | nM | 6.62 |
| CHEMBL5436520 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL5435510 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL5407945 | — | Ki | = | 342.0 | nM | 6.47 |
| CHEMBL5395819 | — | Ki | = | 353.0 | nM | 6.45 |
| CHEMBL5400651 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL5396300 | — | Ki | = | 525.0 | nM | 6.28 |
| CHEMBL5408237 | — | Ki | = | 526.0 | nM | 6.28 |
| CHEMBL5418191 | — | Ki | = | 573.0 | nM | 6.24 |
| CHEMBL5415738 | — | Ki | = | 621.0 | nM | 6.21 |
| CHEMBL5415788 | — | Ki | = | 664.0 | nM | 6.18 |
| CHEMBL5428774 | — | Ki | = | 723.0 | nM | 6.14 |
| CHEMBL5396579 | — | Ki | = | 862.0 | nM | 6.06 |
| CHEMBL5415255 | — | Ki | = | 1010.0 | nM | 6.00 |
| CHEMBL5412463 | — | Ki | = | 1004.0 | nM | 6.00 |
| CHEMBL5425014 | — | Ki | = | 1036.0 | nM | 5.99 |
| CHEMBL5415576 | — | Ki | = | 1334.0 | nM | 5.88 |
| CHEMBL5416363 | — | Ki | = | 1347.0 | nM | 5.87 |
| CHEMBL5406306 | — | Ki | = | 1525.0 | nM | 5.82 |
| CHEMBL5399641 | — | Ki | = | 1646.0 | nM | 5.78 |
| CHEMBL5432840 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL5415482 | — | Ki | = | 3107.0 | nM | 5.51 |
| CHEMBL5396724 | — | Ki | = | 27000.0 | nM | 4.57 |