Assay Detail
Binding
CHEMBL5316662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cell surface anchored CD73 (unknown origin) expressed in human SK-MEL-28 cells incubated for 30 mins by malachite green assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates <i>In Vivo</i> Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.84 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423436 | — | — | 1 | 9.68 |
| CHEMBL5393743 | — | — | 1 | 8.55 |
| CHEMBL5404019 | — | — | 1 | 6.77 |
| CHEMBL5402847 | — | — | 1 | 6.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423436 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5393743 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL5404019 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL5402847 | — | IC50 | = | 434.0 | nM | 6.36 |