Assay Detail
Binding
CHEMBL5316717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human CD73
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Series of Potent, Selective, and Orally Bioavailable Nucleoside Inhibitors of CD73 That Demonstrates <i>In Vivo</i> Antitumor Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.77 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5403031 | — | — | 1 | 8.05 |
| CHEMBL5402847 | — | — | 1 | 7.00 |
| CHEMBL5409473 | — | — | 1 | 6.80 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5403031 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5402847 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5409473 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL583969 | PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | IC50 | = | 6090.0 | nM | 5.21 |